RT Book, Section
A1 Manno, Rebecca L.
A1 Yazdany, Jinoos
A1 Tarrant, Teresa K.
A1 Kwan, Mildred
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1193126066
T1 Arthritis In Sarcoidosis
T2 Current Medical Diagnosis & Treatment 2023
YR 2023
FD 2023
PB McGraw-Hill Education
PP New York, NY
SN 9781264687343
LK accessmedicine.mhmedical.com/content.aspx?aid=1193126066
RD 2024/10/05
AB Arthritis  as  a  feature  of  sarcoidosis  occurs  in  10–35%  of  patients.  It  is  usually  acute  in  onset,  but  articular  symptoms  may  appear  insidiously  and  antedate  other  manifestations  of  the  disease.  Knees  and  ankles  are  most  commonly  involved,  but  any  joint  can  be  affected.  Distribution  of  joint  involvement  is  usually  polyarticular  and  symmetric.  The  arthritis  is  commonly  self-limited,  resolving  after  several  weeks  or  months  and  rarely  resulting  in  chronic  arthritis,  joint  destruction,  or  significant  deformity.  Sarcoid  arthropathy  is  often  associated  with  erythema  nodosum,  but  the  diagnosis  is  contingent  on  the  demonstration  of  other  extra-articular  manifestations  of  sarcoidosis  and,  notably,  biopsy  evidence  of  noncaseating  granulomas.  Despite  the  clinical  appearance  of  an  inflammatory  arthritis,  synovial  fluid  often  is  noninflammatory  (ie,  less  than  2000  leukocytes/mcL  [2.0  ×  109/L]).  In  chronic  arthritis,  radiographs  show  typical  changes  in  the  bones  of  the  extremities  with  intact  cortex  and  cystic  changes.