RT Book, Section
A1 Chen, Peng-Sheng
A1 Ho, Siew Yen
A1 Priori, Silvia G.
A1 Antzelevitch, Charles
A2 Fuster, Valentin
A2 Narula, Jagat
A2 Vaishnava, Prashant
A2 Leon, Martin B.
A2 Callans, David J.
A2 Rumsfeld, John S.
A2 Poppas, Athena
SR Print(0)
ID 1202446868
T1 Electrophysiologic Anatomy, Mechanisms of Arrhythmias and Conduction Disturbances, and Genetics
T2 Fuster and Hurst's The Heart, 15e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264257560
LK accessmedicine.mhmedical.com/content.aspx?aid=1202446868
RD 2024/04/23
AB Chapter  SummaryThis  chapter  examines  our  present  understanding  of  anatomical,  cellular,  ionic,  and  molecular  mechanisms  responsible  for  cardiac  arrhythmias  (see  Fuster  and  Hurst’s  Central  Illustration).  The  anatomical  basis  of  cardiac  arrhythmia  is  first  discussed,  with  focus  on  the  spatial  relationships  of  cardiac  and  neighborhood  structures  when  maneuvering  catheters  in  and  around  the  heart.  The  generation  and  maintenance  of  cardiac  arrhythmias  and  conduction  disturbances  depend  on  the  interactions  of  various  genetic,  molecular,  fixed,  and  dynamic  factors.  Recent  years  have  witnessed  important  advances  in  our  understanding  of  the  structural,  molecular,  and  electrophysiologic  mechanisms,  fueled  by  innovative  research  into  the  genetic  basis  and  predisposition  for  electrical  dysfunction  of  the  heart.  These  advances  notwithstanding,  our  appreciation  of  the  basis  for  many  rhythm  disturbances  is  still  incomplete.  While  it  is  not  possible  to  comprehensively  review  all  important  literature  in  this  book  chapter,  we  tried  to  examine  new  insights  obtained  from  recent  studies  and  put  them  into  historical  perspective  whenever  possible.