RT Book, Section A1 Hasler, William L. A1 Owyang, Chung A2 Loscalzo, Joseph A2 Fauci, Anthony A2 Kasper, Dennis A2 Hauser, Stephen A2 Longo, Dan A2 Jameson, J. Larry SR Print(0) ID 1198711238 T1 Approach to the Patient with Gastrointestinal Disease T2 Harrison's Principles of Internal Medicine, 21e YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264268504 LK accessmedicine.mhmedical.com/content.aspx?aid=1198711238 RD 2024/04/23 AB The gastrointestinal (GI) tract extends from the mouth to the anus and is composed of organs with distinct functions. Sphincters that assist in gut compartmentalization separate the organs. The gut wall is organized into distinct layers that contribute to regional activities. The mucosa is a barrier to luminal contents or a site for fluid and nutrient transfer. Smooth muscle in association with the enteric nervous system mediates propulsion between regions. Many GI organs possess a serosal layer that provides a supportive foundation and permits external input.