RT Book, Section A1 Cohen, Jeffrey I. A2 Loscalzo, Joseph A2 Fauci, Anthony A2 Kasper, Dennis A2 Hauser, Stephen A2 Longo, Dan A2 Jameson, J. Larry SR Print(0) ID 1198223796 T1 Epstein-Barr Virus Infections, Including Infectious Mononucleosis T2 Harrison's Principles of Internal Medicine, 21e YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264268504 LK accessmedicine.mhmedical.com/content.aspx?aid=1198223796 RD 2024/09/11 AB Epstein-Barr virus (EBV) is the cause of heterophile-positive infectious mononucleosis (IM), which is characterized by fever, sore throat, lymphadenopathy, and atypical lymphocytosis. EBV is also associated with several tumors, including nasopharyngeal and gastric carcinoma, Burkitt’s lymphoma, Hodgkin’s lymphoma, T-cell lymphoma, and (in patients with immunodeficiencies) B-cell lymphoma and smooth muscle tumors. The virus is a member of the family Herpesviridae. The two types of EBV that are widely prevalent in nature are not distinguishable by conventional serologic tests.