RT Book, Section
A1 Varadhachary, Gauri R.
A1 Raghav, Kanwal P.
A1 Huey, Ryan W.
A2 Kantarjian, Hagop M.
A2 Wolff, Robert A.
A2 Rieber, Alyssa G.
SR Print(0)
ID 1190838917
T1 Carcinoma of Unknown Primary
T2 The MD Anderson Manual of Medical Oncology, 4e
YR 2022
FD 2022
PB McGraw Hill Education
PP New York, NY
SN 9781260467642
LK accessmedicine.mhmedical.com/content.aspx?aid=1190838917
RD 2024/04/25
AB KEY  CONCEPTSCarcinoma  of  unknown  primary  (CUP)  is  defined  as  biopsy-proven  metastatic  cancer  where  a  primary  site  is  unidentifiable  after  adequate  workup.CUP  is  a  rare  tumor  with  an  incidence  of  less  than  10  per  100,000  individuals  and  constitutes  nearly  2%  of  all  cancers  diagnosed  in  the  United  States.Favorable  and  specific  clinicopathologic  subsets  in  CUP  should  be  identified  and  treated  with  selective  and  aggressive  treatments.Limited  data  support  the  use  and  therapeutic  impact  of  molecular  profiling  assays  for  tissue  of  origin  (ToO)  determination  in  CUP.Chemotherapy  for  patients  with  CUP  can  be  either  empiric  or  site-specific  (guided  by  putative  primary  site  determined  by  clinicopathologic  factors),  and  novel  effective  therapies  for  known  primaries  may  impact  the  treatment  decision.Overall  prognosis  in  CUP  is  poor,  but  a  great  degree  of  heterogeneity  based  on  patient  and  disease  characteristics  exists.