RT Book, Section
A1 Sacks, Ruth
A1 Boyce-Fappiano, David
A1 Moreno, Amy
A1 Mott, Frank
A2 Kantarjian, Hagop M.
A2 Wolff, Robert A.
A2 Rieber, Alyssa G.
SR Print(0)
ID 1190834897
T1 Head and Neck Cancer
T2 The MD Anderson Manual of Medical Oncology, 4e
YR 2022
FD 2022
PB McGraw Hill Education
PP New York, NY
SN 9781260467642
LK accessmedicine.mhmedical.com/content.aspx?aid=1190834897
RD 2024/04/18
AB KEY  CONCEPTSHead  and  neck  cancers  are  diverse.  In  this  chapter,  we  focus  on  the  management  of  squamous  cell  carcinomas  of  the  head  and  neck  (HNSCC).Tobacco  and  alcohol  use  are  major  risk  factors,  and  the  human  papillomavirus  (HPV)  is  a  risk  factor  for  oropharyngeal  cancer  (OPC).All  patients  should  undergo  a  multidisciplinary  evaluation  that  includes  surgical,  medical,  and  radiation  oncology  specialists.For  early-stage  HNSCC,  surgery  or  definitive  radiation  provides  excellent  local  control.Most  patients  present  with  locally  advanced  disease  requiring  a  multimodality  approach  focusing  on  organ  preservation,  managing  metastatic  risk,  and  minimizing  acute  and  chronic  toxicities.Immune  checkpoint  inhibitors  are  now  standard  in  recurrent  and/or  metastatic  HNSCC.