RT Book, Section
A1 Gupta, Kalpana
A1 Trautner, Barbara W.
A2 Loscalzo, Joseph
A2 Fauci, Anthony
A2 Kasper, Dennis
A2 Hauser, Stephen
A2 Longo, Dan
A2 Jameson, J. Larry
SR Print(0)
ID 1201012844
T1 Urinary Tract Infections, Pyelonephritis, and Prostatitis
T2 Harrison's Principles of Internal Medicine, 21e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264268504
LK accessmedicine.mhmedical.com/content.aspx?aid=1201012844
RD 2024/10/06
AB Urinary  tract  infection  (UTI)  is  a  common  and  painful  human  illness  that  is  rapidly  responsive  to  modern  antibiotic  therapy,  if  the  correct  antibiotic  is  chosen  for  the  particular  urinary  pathogen.  In  the  preantibiotic  era,  UTI  caused  significant  morbidity.  Hippocrates,  writing  about  a  disease  that  appears  to  have  been  acute  cystitis,  said  that  the  illness  could  last  for  a  year  before  either  resolving  or  worsening  to  involve  the  kidneys.  When  chemotherapeutic  agents  used  to  treat  UTI  were  introduced  in  the  early  twentieth  century,  they  were  relatively  ineffective,  and  persistence  of  infection  after  3  weeks  of  therapy  was  common.  Nitrofurantoin,  which  became  available  in  the  1950s,  was  the  first  tolerable  and  effective  agent  for  the  treatment  of  UTI.