RT Book, Section A1 Pandey, Ambarish A1 Kondamudi, Nitin A1 Lavie, Carl J. A2 Fuster, Valentin A2 Narula, Jagat A2 Vaishnava, Prashant A2 Leon, Martin B. A2 Callans, David J. A2 Rumsfeld, John S. A2 Poppas, Athena SR Print(0) ID 1202443154 T1 Sedentary Lifestyle and Role of Exercise in Cardiovascular Diseases T2 Fuster and Hurst's The Heart, 15e YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264257560 LK accessmedicine.mhmedical.com/content.aspx?aid=1202443154 RD 2024/04/19 AB Chapter SummaryThis chapter discusses the effects of sedentary lifestyle and physical activity (PA) on cardiovascular disease (CVD) and cardiovascular health. PA and cardiorespiratory fitness (CRF) are risk factors for CVD and have garnered attention as targets for primary and secondary prevention of CVD. Low PA and CRF are independently associated with atherosclerotic CVD as well as heart failure (HF). Sedentary lifestyle contributes to CVD risk through excess burden of CVD risk factors and development of intermediate at-risk phenotypes (see Fuster and Hurst’s Central Illustration). Among individuals with prevalent CVD, low PA and CRF levels portend higher risk of adverse outcomes. However, adoption of healthy exercise behavior and adherence to guideline-recommended levels of PA are low in the general population due to individual, interpersonal, and societal barriers. Identification of these barriers to PA may help inform strategies for PA promotion at an individual, community, and societal level. By increasing healthcare provider awareness of the salutary effects of PA, equipping providers with the training and resources needed to optimize PA adherence, and leveraging a multidisciplinary approach to PA promotion, society can move closer toward realizing the cardiovascular benefits of an active lifestyle.