RT Book, Section
A1 Russo, Thomas A.
A1 Johnson, James R.
A2 Loscalzo, Joseph
A2 Fauci, Anthony
A2 Kasper, Dennis
A2 Hauser, Stephen
A2 Longo, Dan
A2 Jameson, J. Larry
SR Print(0)
ID 1198221493
T1 Diseases Caused by Gram-Negative Enteric Bacilli
T2 Harrison's Principles of Internal Medicine, 21e
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264268504
LK accessmedicine.mhmedical.com/content.aspx?aid=1198221493
RD 2024/04/24
AB The  post-antibiotic  era  has  begun.  For  most  people,  this  is  the  first  time  in  their  lives  that  an  effective  treatment  for  a  bacterial  infection  may  not  exist.  The  Enterobacteriaceae  are  at  the  forefront  of  this  evolving  public  health  crisis.  For  example,  the  Centers  for  Disease  Control  and  Prevention  (CDC)  and  the  World  Health  Organization  (WHO)  have  designated  carbapenem-resistant  Enterobacteriaceae  (CRE)  as  representing  a  threat  level  of  “urgent”  and  “priority  one,  critical.”  Enterobacteriaceae  are  responsible  for  a  significant  proportion  of  the  deaths  attributed  to  antimicrobial-resistant  bacteria,  of  which  an  estimated  23,000  and  25,000  occur  annually  in  the  United  States  and  the  European  Union,  respectively,  and  three  to  five  times  as  many  (per  capita)  in  low-  and  middle-income  countries  (e.g.,  Thailand).  These  pathogens  cause  a  wide  variety  of  infections  involving  diverse  anatomic  sites  in  both  healthy  and  compromised  hosts.  Therefore,  a  thorough  knowledge  of  clinical  presentations  and  appropriate  therapeutic  choices  is  necessary  for  optimal  outcomes.  Escherichia  coli,  Klebsiella,  Proteus,  Enterobacter,  Serratia,  Citrobacter,  Morganella,  Providencia,  Cronobacter,  and  Edwardsiella  are  enteric  gram-negative  bacilli  (GNB)  within  the  family  Enterobacteriaceae  that  commonly  cause  extraintestinal  infections.  Salmonella,  Shigella,  and  Yersinia,  which  also  are  in  the  family  Enterobacteriaceae  but  more  commonly  cause  gastrointestinal  infections,  are  discussed  in  Chaps.  165,  166,  and  171,  respectively.