RT Book, Section A1 Weinstein, Robert A. A2 Loscalzo, Joseph A2 Fauci, Anthony A2 Kasper, Dennis A2 Hauser, Stephen A2 Longo, Dan A2 Jameson, J. Larry SR Print(0) ID 1190479711 T1 Infections Acquired in Health Care Facilities T2 Harrison's Principles of Internal Medicine, 21e YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264268504 LK accessmedicine.mhmedical.com/content.aspx?aid=1190479711 RD 2024/04/16 AB Health care–associated infections affect at least 2 million patients at a cost of billions of dollars and 100,000 or more lives in U.S. hospitals annually. Guidelines from the Centers for Disease Control and Prevention (CDC) (www.cdc.gov/hicpac/), the Agency for Healthcare Research and Quality (www.ahrq.gov), and professional societies (e.g., www.shea-online.org; www.idsociety.org; www.apic.org; www.his.org.uk) have led to marked reductions in occurrence of most device-related infections (https://www.cdc.gov/hai/data/portal/progress-report.html)—historically, the largest drivers of nosocomial infection risk. Despite these successes, there is the seemingly unending threat of antimicrobial-resistant infections and novel pathogens. This chapter reviews the epidemiology, prevention, and control of health care–associated infections and newer challenges.