RT Book, Section A1 DeAngelis, Lisa M. A1 Wen, Patrick Y. A2 Loscalzo, Joseph A2 Fauci, Anthony A2 Kasper, Dennis A2 Hauser, Stephen A2 Longo, Dan A2 Jameson, J. Larry SR Print(0) ID 1203311990 T1 Primary and Metastatic Tumors of the Nervous System T2 Harrison's Principles of Internal Medicine, 21e YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264268504 LK accessmedicine.mhmedical.com/content.aspx?aid=1203311990 RD 2024/03/29 AB An estimated 87,000 people will be diagnosed with a primary brain tumor annually in the United States. At least 25,000 of these tumors are malignant, and most of these are gliomas. Meningiomas account for 35%, vestibular schwannomas 10%, and central nervous system (CNS) lymphomas ~2%. Brain metastases are three times more common than all primary brain tumors combined and are diagnosed in ~150,000 people each year. Metastases to the leptomeninges and epidural space of the spinal cord each occur in ~3–5% of patients with systemic cancer and are also a major cause of neurologic disability.