RT Book, Section A1 Stringer, Janet L. SR Print(0) ID 1187634499 T1 Adrenocortical Hormones T2 Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 6e YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264264841 LK accessmedicine.mhmedical.com/content.aspx?aid=1187634499 RD 2024/03/28 AB Now would be a good time to do a quick review of the anatomy of the adrenal gland and the normal release of cortisol and aldosterone. Remember that the adrenal medulla produces epinephrine and norepinephrine. Within the adrenal cortex, there are three layers. The zona glomerulosa (outer layer) produces the compounds that control electrolyte balance, such as aldosterone. The zona fasciculata (middle layer) produces the compounds that regulate metabolism, such as hydrocortisone. The zona reticularis (inner layer) produces the sex hormones (see Chapter 39). The pituitary hormone adrenocorticotropic hormone (ACTH) controls the secretion of, primarily, the inner two layers. The production of mineralocorticoids is mainly controlled by the renin-angiotensin system.