RT Book, Section A1 Stringer, Janet L. SR Print(0) ID 1187633111 T1 Absorption, Distribution, and Clearance T2 Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 6e YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264264841 LK accessmedicine.mhmedical.com/content.aspx?aid=1187633111 RD 2024/04/24 AB The liver is a metabolic machine and often inactivates drugs on their way from the gastrointestinal (GI) tract to the body. This is called the first-pass effect.