RT Book, Section A1 Laposata, Michael A1 McCaffrey, Peter SR Print(0) ID 1187001255 T1 Methods in Clinical Chemistry and General Methods T2 Clinical Laboratory Methods: Atlas of Commonly Performed Tests YR 2022 FD 2022 PB McGraw Hill, LLC PP New York, NY SN 9781260470284 LK accessmedicine.mhmedical.com/content.aspx?aid=1187001255 RD 2024/04/19 AB The concentrations of the major electrolytes in venous plasma or serum can be determined using ion-selective electrodes for each one. The major ones are sodium (Na), potassium (K), and chloride (Cl). A major preanalytical error involves aggressive handling of the tube (shaking instead of gentle inversion) prior to analysis. It is frequently manifested by an artifactually high value for potassium. Ionized or free calcium, not bound to protein, can also be measured using an electrode specific for calcium.