RT Book, Section A1 Gonzalez, Alex A2 Keuroghlian, Alex S. A2 Potter, Jennifer A2 Reisner, Sari L. SR Print(0) ID 1184177127 T1 Screening for Cancer and Cardiovascular T2 Transgender and Gender Diverse Health Care: The Fenway Guide YR 2022 FD 2022 PB McGraw Hill PP New York, NY SN 9781260459937 LK accessmedicine.mhmedical.com/content.aspx?aid=1184177127 RD 2024/04/24 AB Heart disease and cancer are the two leading causes of death in the general population in the United States,1 but their impact on transgender and gender diverse (TGD) people is poorly understood. Gender-affirming hormone therapy (GAHT) can play a role in the development of certain cancers, and may worsen some risk factors for cardiovascular disease. Societal and health care sector marginalization of TGD people—via economic disenfranchisement, increased risky behavior, decreased access to care, decreased patient willingness to seek care, and increased stigma—can contribute to higher oncologic and cardiovascular risk as well. This chapter will review what we know about cancer and cardiovascular disease epidemiology in TGD people as well as how to approach screening for these diseases in a primary care setting.