RT Book, Section A1 Luke, Anthony A1 Ma, C. Benjamin A2 Papadakis, Maxine A. A2 McPhee, Stephen J. A2 Rabow, Michael W. A2 McQuaid, Kenneth R. SR Print(0) ID 1184191400 T1 Spine Problems T2 Current Medical Diagnosis & Treatment 2022 YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264269389 LK accessmedicine.mhmedical.com/content.aspx?aid=1184191400 RD 2024/04/19 AB KEY CLINICAL UPDATES IN SPINE PROBLEMSExercise, oral NSAIDs, and serotonin and norepinephrine reuptake inhibitors (duloxetine) were shown in a systematic review to produce a clinically meaningful reduction in pain, with exercise being the only intervention that demonstrated sustained benefit after the intervention ended.A 2021 meta-analysis comparing fusion and nonfusion surgeries for lumbar spinal stenosis found no difference in clinical effects and complications, highlighting the challenge of surgical intervention for lumbar spinal stenosis.A 2020 Cochrane review of 25 placebo-controlled trials provides moderate-quality evidence that epidural corticosteroid injections are effective, although the treatment effects are small (mean difference < 10%) and short-term for improving radicular pain for individuals.There is level I evidence for the use of transforaminal injections for radicular pain from disk herniation.