RT Book, Section
A1 Smollin, Craig
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1184179769
T1 Methemoglobinemia-Inducing Agents Poisoning
T2 Current Medical Diagnosis & Treatment 2022
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269389
LK accessmedicine.mhmedical.com/content.aspx?aid=1184179769
RD 2024/04/24
AB A  large  number  of  chemical  agents  are  capable  of  oxidizing  ferrous  hemoglobin  to  its  ferric  state  (methemoglobin),  a  form  that  cannot  carry  oxygen.  Drugs  and  chemicals  known  to  cause  methemoglobinemia  include  benzocaine  (a  local  anesthetic  found  in  some  topical  anesthetic  sprays  and  a  variety  of  nonprescription  products),  aniline,  propanil  (an  herbicide),  nitrites,  nitrogen  oxide  gases,  nitrobenzene,  dapsone,  phenazopyridine  (Pyridium),  and  many  others.  Dapsone  has  a  long  elimination  half-life  and  may  produce  prolonged  or  recurrent  methemoglobinemia.  Amyl  nitrite  and  isobutyl  nitrite  (“poppers”)  are  inhaled  as  sexual  stimulants  but  can  result  in  methemoglobinemia.