RT Book, Section
A1 Smollin, Craig
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1184179676
T1 Iron Overdose
T2 Current Medical Diagnosis & Treatment 2022
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269389
LK accessmedicine.mhmedical.com/content.aspx?aid=1184179676
RD 2024/04/23
AB Iron  is  widely  used  therapeutically  for  the  treatment  of  anemia  and  as  a  daily  supplement  in  multiple  vitamin  preparations.  Most  children's  preparations  contain  about  12–15  mg  of  iron  (as  sulfate,  gluconate,  or  fumarate  salt)  per  dose,  compared  with  60–90  mg  in  most  adult-strength  preparations.  Iron  is  corrosive  to  the  gastrointestinal  tract  and,  once  absorbed,  has  depressant  effects  on  the  myocardium  and  on  peripheral  vascular  resistance.  Intracellular  toxic  effects  of  iron  include  disruption  of  Krebs  cycle  enzymes.  Carbonyl  iron  is  a  powdered  form  of  elemental  iron.  It  is  not  as  irritating  to  the  gastrointestinal  tract  as  the  iron  salts  and  appears  to  be  safer.