RT Book, Section A1 Saunders, Katherine H. A1 Igel, Leon I. A2 Papadakis, Maxine A. A2 McPhee, Stephen J. A2 Rabow, Michael W. A2 McQuaid, Kenneth R. SR Print(0) ID 1184163063 T1 Vitamin E Toxicity T2 Current Medical Diagnosis & Treatment 2022 YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264269389 LK accessmedicine.mhmedical.com/content.aspx?aid=1184163063 RD 2024/04/25 AB Clinical trials have suggested an increase in all-cause mortality with high dose (greater than 400 international units/day) vitamin E supplements. Large doses of vitamin E can also increase the vitamin K requirement and result in bleeding in patients taking oral anticoagulants.