RT Book, Section
A1 Fitzgerald, Paul A.
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1184697797
T1 Primary Adrenal Insufficiency (Addison Disease)
T2 Current Medical Diagnosis & Treatment 2022
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269389
LK accessmedicine.mhmedical.com/content.aspx?aid=1184697797
RD 2024/04/19
AB ESSENTIALS  OF  DIAGNOSISDeficiency  of  cortisol  and  mineralocorticoid  from  destruction  of  the  adrenal  cortex.Weakness,  vomiting,  diarrhea;  abdominal  pain,  arthralgias;  amenorrhea.Increased  skin  pigmentation,  especially  of  creases,  pressure  areas,  and  nipples.Hypovolemic  hypotension,  small  heart.Hyponatremia;  hyperkalemia  (may  be  absent  with  vomiting  and  diarrhea);  hypoglycemia;  eosinophilia.Elevated  plasma  ACTH  level;  cosyntropin  unable  to  stimulate  serum  cortisol  to  ≥  20  mcg/dL  (550  nmol/L).Acute  adrenal  crisis:  above  manifestations  become  critical,  with  fever,  shock,  confusion,  coma,  death.