RT Book, Section A1 Dirkx, Tonja C. A1 Woodell, Tyler B. A2 Papadakis, Maxine A. A2 McPhee, Stephen J. A2 Rabow, Michael W. A2 McQuaid, Kenneth R. SR Print(0) ID 1184183407 T1 Renal Amyloidosis T2 Current Medical Diagnosis & Treatment 2022 YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264269389 LK accessmedicine.mhmedical.com/content.aspx?aid=1184183407 RD 2024/03/28 AB Amyloidosis is a relatively rare cause of nephrotic syndrome. It is caused by tissue deposition of an overproduced and abnormally folded protein (amyloid). Several different proteins can form amyloid fibrils with renal deposition. Primary amyloidosis, or AL amyloidosis, is the most common form and is due to a plasma cell dyscrasia causing overproduction and deposition of monoclonal Ig light chains (see Chapter 13). Secondary amyloidosis, or AA amyloidosis, can rarely occur in chronic inflammatory disease such as rheumatoid arthritis, inflammatory bowel disease, or chronic infection; in these cases, there is deposition of an acute phase reactant, serum amyloid A protein. Other less common forms of amyloidosis may also be encountered.