RT Book, Section
A1 Dirkx, Tonja C.
A1 Woodell, Tyler B.
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1184183366
T1 Focal Segmental Glomerulosclerosis
T2 Current Medical Diagnosis & Treatment 2022
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269389
LK accessmedicine.mhmedical.com/content.aspx?aid=1184183366
RD 2024/04/19
AB This  relatively  common  renal  pattern  of  injury  results  from  damage  to  podocytes;  such  damage  may  be  a  primary/renal-limited  disorder  or  may  be  secondary  to  another  underlying  disease  state.  Primary  causes  fall  into  three  categories:  (1)  heritable  abnormalities  in  any  one  of  several  podocyte  proteins,  or  to  underlying  type  4  collagen  mutations;  (2)  polymorphisms  in  the  APOL1  gene  in  those  of  African  ancestry;  or  (3)  increased  levels  of  a  circulating  permeability  factor.  Secondary  causes  include  renal  overwork  injury,  obesity,  hypertension,  chronic  urinary  reflux,  HIV  or  SARS-CoV-2  infection,  or  analgesic  or  bisphosphonate  exposure.  Genetic  testing  in  primary  cases  is  becoming  more  common,  especially  in  the  pediatric  population.