RT Book, Section A1 Arora, Nayan A1 Jefferson, J. Ashley A2 Papadakis, Maxine A. A2 McPhee, Stephen J. A2 Rabow, Michael W. A2 McQuaid, Kenneth R. SR Print(0) ID 1184182803 T1 Normal Anion Gap Acidosis T2 Current Medical Diagnosis & Treatment 2022 YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264269389 LK accessmedicine.mhmedical.com/content.aspx?aid=1184182803 RD 2024/04/19 AB The two major causes of hyperchloremic metabolic acidosis are HCO3– loss from the GI tract or defects in renal acidification (RTA) (Table 21–12 and Table 21–14). The compensatory increase in serum chloride (hyperchloremia) maintains electroneutrality and a normal anion gap. The urinary anion gap can help differentiate between these causes.