RT Book, Section
A1 Yazdany, Jinoos
A1 Manno, Rebecca L.
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1184193826
T1 Primary Immunodeficiency Disorders in Adults
T2 Current Medical Diagnosis & Treatment 2022
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269389
LK accessmedicine.mhmedical.com/content.aspx?aid=1184193826
RD 2024/04/20
AB Primary  immunologic  deficiency  diseases  are  estimated  to  affect  1  in  4000  individuals;  many  are  genetically  determined  and  present  in  childhood.  Nonetheless,  several  important  immunodeficiency  disorders  present  in  adulthood,  most  notably  the  antibody  deficiency  syndromes:  selective  IgA  deficiency,  common  variable  immunodeficiency,  and  specific  (functional)  antibody  deficiency  (Table  20–14).  Antibody  deficiency  predisposes  patients  to  recurrent  infections,  particularly  of  the  respiratory  tract,  including  refractory  chronic  rhinosinusitis,  bronchitis,  pneumonia,  and  bronchiectasis.  Patients  are  most  susceptible  to  infections  with  encapsulated  bacteria  (eg,  Haemophilus  influenzae  type  b,  Streptococcus  pneumoniae,  Neisseriameningitides).  However,  any  part  of  the  innate  or  adaptive  immune  system  can  be  defective  and  results  in  infections  with  different  spectra  of  organisms.