RT Book, Section
A1 Yazdany, Jinoos
A1 Manno, Rebecca L.
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1184193436
T1 Seronegative Spondyloarthropathies
T2 Current Medical Diagnosis & Treatment 2022
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269389
LK accessmedicine.mhmedical.com/content.aspx?aid=1184193436
RD 2023/10/04
AB The  seronegative  spondyloarthropathies  are  ankylosing  spondylitis,  psoriatic  arthritis,  reactive  arthritis,  the  arthritis  associated  with  inflammatory  bowel  disease,  and  undifferentiated  spondyloarthropathy.  These  disorders  are  noted  for  male  predominance,  onset  usually  before  age  40,  inflammatory  arthritis  of  the  spine  and  sacroiliac  joints,  asymmetric  oligoarthritis  of  large  peripheral  joints,  enthesopathy  (inflammation  of  where  ligaments,  tendons,  and  joint  capsule  insert  into  bone),  ocular  inflammation,  the  absence  of  autoantibodies,  and  a  striking  association  with  HLA-B27  (eTable  20–1).  HLA-B27  is  positive  in  up  to  90%  of  patients  with  ankylosing  spondylitis  and  75%  with  reactive  arthritis.  HLA-B27  also  occurs  in  50%  of  the  psoriatic  and  inflammatory  bowel  disease  patients  who  have  sacroiliitis.  Patients  with  only  peripheral  arthritis  in  these  latter  two  syndromes  do  not  show  an  increase  in  HLA-B27.