RT Book, Section A1 Yazdany, Jinoos A1 Manno, Rebecca L. A2 Papadakis, Maxine A. A2 McPhee, Stephen J. A2 Rabow, Michael W. A2 McQuaid, Kenneth R. SR Print(0) ID 1184193052 T1 Rheumatoid Arthritis T2 Current Medical Diagnosis & Treatment 2022 YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264269389 LK accessmedicine.mhmedical.com/content.aspx?aid=1184193052 RD 2024/04/19 AB ESSENTIALS OF DIAGNOSISUsually insidious onset with morning stiffness and joint pain.Symmetric polyarthritis with predilection for small joints of the hands and feet; deformities common with progressive disease.Radiographic findings: juxta-articular osteoporosis, joint erosions, and joint space narrowing.Rheumatoid factor and antibodies to cyclic citrullinated peptides (anti-CCP) are present in 70–80%.Extra-articular manifestations: subcutaneous nodules, interstitial lung disease, pleural effusion, pericarditis, splenomegaly with leukopenia, scleritis, and vasculitis.