RT Book, Section
A1 Leavitt, Andrew D.
A1 Price, Erika Leemann
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1184168409
T1 Overview of Hemostasis
T2 Current Medical Diagnosis & Treatment 2022
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269389
LK accessmedicine.mhmedical.com/content.aspx?aid=1184168409
RD 2024/04/19
AB Hemostasis,  the  physiologic  process  that  maintains  vascular  integrity  and  minimizes  bleeding  in  the  face  of  injury,  requires  a  complex  and  coordinated  interplay  of  cellular  elements  (platelets)  and  humoral  (clotting)  factors  working  in  concert.  Platelets  are  exposed  to  collagen,  fibronectin,  and  other  molecules  in  the  subendothelial  matrix  at  the  site  of  vascular  injury,  which  leads  to  platelet  adherence,  activation,  and  aggregation  to  form  an  initial  platelet  plug,  a  process  that  can  be  viewed  as  primary  hemostasis.  von  Willebrand  factor  (vWF)  facilitates  platelet  adherence  to  subendothelial  collagen  at  the  site  of  endothelial  injury,  especially  in  high-shear  areas  such  as  arterioles.  While  vWF  also  helps  cross-link  platelets,  soluble  fibrinogen  is  the  primary  molecule  that  links  platelets  together  to  form  the  platelet  plug.