RT Book, Section
A1 Damon, Lloyd E.
A1 Andreadis, Charalambos Babis
A2 Papadakis, Maxine A.
A2 McPhee, Stephen J.
A2 Rabow, Michael W.
A2 McQuaid, Kenneth R.
SR Print(0)
ID 1184165868
T1 Sickle Cell Trait
T2 Current Medical Diagnosis & Treatment 2022
YR 2022
FD 2022
PB McGraw-Hill Education
PP New York, NY
SN 9781264269389
LK accessmedicine.mhmedical.com/content.aspx?aid=1184165868
RD 2024/04/19
AB People  with  the  heterozygous  hemoglobin  genotype  AS  have  sickle  cell  trait.  These  persons  are  hematologically  normal,  with  no  anemia  and  normal  red  blood  cells  on  peripheral  blood  smear.  A  screening  test  for  sickle  hemoglobin  will  be  positive,  and  Hemoglobin  electrophoresis  will  reveal  that  approximately  40%  of  hemoglobin  is  hemoglobin  S  (Table  13–9).  People  with  sickle  cell  trait  experience  more  rhabdomyolysis  during  vigorous  exercise  but  do  not  have  increased  mortality  compared  to  the  general  population.  They  may  be  at  increased  risk  for  venous  thromboembolism.  Chronic  sickling  of  red  blood  cells  in  the  acidotic  renal  medulla  results  in  microscopic  and  gross  hematuria,  hyposthenuria  (poor  urine  concentrating  ability),  and  possibly  chronic  kidney  disease.  No  treatment  is  necessary  but  genetic  counseling  is  recommended.