RT Book, Section A1 Fitzpatrick, Meghan E. A1 Prendergast, Niall T. A1 Rivera-Lebron, Belinda A2 Papadakis, Maxine A. A2 McPhee, Stephen J. A2 Rabow, Michael W. A2 McQuaid, Kenneth R. SR Print(0) ID 1186013196 T1 Pleuritis T2 Current Medical Diagnosis & Treatment 2022 YR 2022 FD 2022 PB McGraw-Hill Education PP New York, NY SN 9781264269389 LK accessmedicine.mhmedical.com/content.aspx?aid=1186013196 RD 2024/04/20 AB Pleuritic pain due to inflammation of the parietal pleura is generally localized, sharp, and fleeting; it is made worse by coughing, sneezing, deep breathing, or movement. When the central portion of the diaphragmatic parietal pleura is irritated, pain may be referred to the ipsilateral shoulder. There are numerous causes of pleuritis. The setting in which pleuritic pain develops helps narrow the differential diagnosis. In young, otherwise healthy individuals, pleuritis is usually caused by viral respiratory infections or pneumonia (including tuberculosis in endemic regions), while PE, inflammatory disorders (serositis), malignancy, and drug reactions may also be considered in the proper context. The presence of pleural effusion, pleural thickening, or air in the pleural space requires further diagnostic and therapeutic measures.