RT Book, Section
A1 Cunningham, F. Gary
A1 Leveno, Kenneth J.
A1 Dashe, Jodi S.
A1 Hoffman, Barbara L.
A1 Spong, Catherine Y.
A1 Casey, Brian M.
SR Print(0)
ID 1190769664
T1 Connective Tissue Disorders
T2 Williams Obstetrics, 26e
YR 2022
FD 2022
PB McGraw Hill
PP New York, NY
SN 9781260462739
LK accessmedicine.mhmedical.com/content.aspx?aid=1190769664
RD 2024/04/20
AB Connective  tissue  disorders,  also  termed  collagen  vascular  disorders,  have  two  basic  underlying  causes.  First  are  the  immune-complex  diseases,  in  which  deposition  of  immune  complexes  causes  connective  tissue  damage.  Because  these  manifest  by  sterile  inflammation—predominantly  of  the  skin,  joints,  blood  vessels,  and  kidneys—they  are  referred  to  as  rheumatic  diseases.  Many  of  these  immune-complex  diseases  are  more  prevalent  in  women,  and  systemic  lupus  erythematosus  (SLE)  and  rheumatoid  arthritis  are  examples.  Second  are  the  inherited  disorders  that  involve  bone,  skin,  cartilage,  blood  vessels,  and  basement  membranes.  These  include  Marfan  syndrome,  osteogenesis  imperfecta,  and  Ehlers-Danlos  syndrome.