RT Book, Section
A1 Sapp, Sarah G. H.
A1 Guagliardo, Sarah Anne J.
A1 Bradbury, Richard S.
A2 Boulton, Matthew L.
A2 Wallace, Robert B.
SR Print(0)
ID 1182666311
T1 Foodborne Trematode Infections
T2 Maxcy-Rosenau-Last Public Health & Preventive Medicine, 16e
YR 2022
FD 2022
PB McGraw Hill
PP New York, NY
SN 9781259644511
LK accessmedicine.mhmedical.com/content.aspx?aid=1182666311
RD 2024/04/18
AB The  trematodes  Clonorchis  sinensis,  Opisthorchis  viverrini,  and  O.  felineus  are  members  of  the  family  Opisthorchidae  and  are  important  causes  of  liver  disease  in  people  within  endemic  areas.  Notably,  and  somewhat  uniquely  among  parasitic  species,  C.  sinensis  and  O.  viverrini  are  classified  as  group  1  carcinogens  due  to  their  association  with  cholangiocarcinoma  and  other  neoplasms  of  the  biliary  system.1  Infections  with  these  “fishborne  liver  flukes”  are  widely  distributed  in  countries  in  the  Far  East  and  Southeast  Asia,  and  countries  of  the  former  Soviet  Union.  They  present  serious  public  health  problems  in  certain  localized  areas  of  China,  Korea,  Thailand,  Laos,  Cambodia,  Vietnam,  and  several  countries  of  the  former  Soviet  Union  and  increasingly  into  Europe.  The  most  recent  estimate  of  global  burden  indicates  45  million  infections  in  the  endemic  Asian  and  European  range;  this  includes  35  million  C.  sinensis  cases,  10  million  O.  viverrini  cases,  and  1.2  million  O.  felineus  cases.2  Up  to  680  million  people  may  be  at  risk  for  infection.2  Globally,  clonorchiasis  and  opisthorciasis  are  associated  with  an  estimated  522,863  and  188,346  disability-adjusted  life  years,  which  is  relatively  high  among  parasitic  helminths.3  With  increased  travel  and  migration  of  populations  at  risk  and  importation  of  indigenous  uncooked  foods  contaminated  with  these  parasites,  infections  have  also  occurred  in  nonendemic  areas.