RT Book, Section A1 Kirk, Martyn A2 Boulton, Matthew L. A2 Wallace, Robert B. SR Print(0) ID 1182665118 T1 Acute Diarrheal Illness—An Overview T2 Maxcy-Rosenau-Last Public Health & Preventive Medicine, 16e YR 2022 FD 2022 PB McGraw Hill PP New York, NY SN 9781259644511 LK accessmedicine.mhmedical.com/content.aspx?aid=1182665118 RD 2024/04/23 AB Acute diarrhea results in substantial morbidity and mortality. Globally, there were an estimated 6.3 billion episodes of diarrheal disease in 2017.1 Among children less than 5 years of age, the incidence is approximately three episodes per person per year, while among older children and adults it is less than one episode per person per year.2 Diarrheal disease is a key cause of childhood mortality. In 2017, the Global Burden of Disease study—a global collaborative effort to understand the burden and causes of morbidity from all causes—estimated that diarrheal diseases resulted in 1.6 million deaths globally, with 533,000 occurring among children less than 5 years old.3 These resulted in 41.4 million Disability Adjusted Life Years (DALY’s) lost, which equates to years of life lost due to ill health, disability, or death.4 Infectious diarrhea is also important for its propensity to spread globally via infected humans and animals and contaminated foods. In countries of all levels of development, there are regular outbreaks of diarrheal disease requiring intervention that are tailored to the pathogen and nature of spread.