RT Book, Section A1 Paneth, Nigel A2 Boulton, Matthew L. A2 Wallace, Robert B. SR Print(0) ID 1182668706 T1 Developmental Disabilities T2 Maxcy-Rosenau-Last Public Health & Preventive Medicine, 16e YR 2022 FD 2022 PB McGraw Hill PP New York, NY SN 9781259644511 LK accessmedicine.mhmedical.com/content.aspx?aid=1182668706 RD 2024/04/19 AB The human species is altricial in comparison to other large mammals, including large primates, and has only a modest supply of motor and cognitive skills at birth. The anatomic substrates of cognition, behavior, and movement are largely set down in utero, but their full functional expression takes many years. Alterations in patterns of in-utero brain development, whether fashioned by genetic abnormalities, by damage from environmental exposures, or by the interaction of these two forces, can damage this anatomic substrate without altering early developmental trajectories in any substantial way. Children born lacking major cortical structures, as in hydranencephaly, are often incapable of expressing the full repertoire of typical human newborn behavior.1