RT Book, Section
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke
A1 Tuan, Rupa Lalchandani
A1 Vanderah, Todd W.
A1 Trevor, Anthony J.
SR Print(0)
ID 1180559028
T1 Immunopharmacology
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 13e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260117127
LK accessmedicine.mhmedical.com/content.aspx?aid=1180559028
RD 2023/03/31
AB The  immune  system  is  essential  for  protection  against  pathogens.  However,  when  dysregulated,  its  powerful  destructive  mechanisms  may  do  more  harm  than  good.  Examples  include  hypersensitivity  reactions,  autoimmune  disorders,  and  rejection  of  transplanted  tissues.  Drugs  that  suppress  immune  mechanisms  play  an  important  role  in  treating  these  conditions.  Increasingly,  monoclonal  antibodies  targeting  proteins  with  key  roles  in  immune  responses  are  being  developed  as  immunosuppressive  agents.  In  some  situations,  drugs  that  potentiate  the  immune  response  provide  benefit.  A  growing  number  of  other  conditions  now  rely  on  monoclonal  antibodies  as  therapeutics  (cancer,  cardiovascular  conditions,  HIV,  etc).  A  small  subset  of  these  newer  drugs  has  been  withdrawn  from  the  market  based  on  emerging  toxicities.