RT Book, Section
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke
A1 Tuan, Rupa Lalchandani
A1 Vanderah, Todd W.
A1 Trevor, Anthony J.
SR Print(0)
ID 1180557877
T1 Tetracyclines, Macrolides, Clindamycin, Chloramphenicol, Streptogramins, & Oxazolidinones
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 13e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260117127
LK accessmedicine.mhmedical.com/content.aspx?aid=1180557877
RD 2024/04/19
AB The  antimicrobial  drugs  reviewed  in  this  chapter  selectively  inhibit  bacterial  protein  synthesis.  The  mechanisms  of  protein  synthesis  in  microorganisms  are  not  identical  to  those  of  mammalian  cells.  Bacteria  have  70S  ribosomes,  whereas  mammalian  cells  have  80S  ribosomes.  Differences  exist  in  ribosomal  subunits  and  in  the  chemical  composition  and  functional  specificities  of  component  nucleic  acids  and  proteins.  Such  differences  form  the  basis  for  the  selective  toxicity  of  these  drugs  against  microorganisms  without  causing  major  effects  on  protein  synthesis  in  mammalian  cells.