RT Book, Section A1 Katzung, Bertram G. A1 Kruidering-Hall, Marieke A1 Tuan, Rupa Lalchandani A1 Vanderah, Todd W. A1 Trevor, Anthony J. SR Print(0) ID 1180557324 T1 NSAIDs, Acetaminophen, & Drugs Used in Rheumatoid Arthritis & Gout T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 13e YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781260117127 LK accessmedicine.mhmedical.com/content.aspx?aid=1180557324 RD 2024/10/13 AB Inflammation is a complex response to cell injury that primarily occurs in vascularized connective tissue and often involves the immune response. The mediators of inflammation function to eliminate the cause of cell injury and clear away debris, in preparation for tissue repair. Unfortunately, inflammation also causes pain and, in instances in which the cause of cell injury is not eliminated, can result in a chronic condition of pain and tissue damage such as that seen in rheumatoid arthritis. The nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen are often effective in controlling inflammatory pain. Other treatment strategies applied to the reduction of inflammation are aimed at immune processes. These include glucocorticoids and disease-modifying antirheumatic drugs (DMARDs), which include conventional synthetic small molecule (csDMARD) and biologic (bDMARD) drugs. Gout is a metabolic disease associated with precipitation of uric acid crystals in joints. Treatment of acute episodes targets inflammation, whereas treatment of chronic gout targets both inflammatory processes and the production and elimination of uric acid.