RT Book, Section
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke
A1 Tuan, Rupa Lalchandani
A1 Vanderah, Todd W.
A1 Trevor, Anthony J.
SR Print(0)
ID 1180556507
T1 Local Anesthetics
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 13e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260117127
LK accessmedicine.mhmedical.com/content.aspx?aid=1180556507
RD 2023/03/24
AB Local  anesthesia  results  when  sensory  transmission  from  a  local  area  of  the  body  to  the  CNS  is  blocked.  The  local  anesthetics  constitute  a  group  of  chemically  similar  agents  (esters  and  amides)  that  block  the  sodium  channels  of  excitable  membranes.  Because  these  drugs  can  be  administered  by  injection  in  the  target  area,  or  by  topical  application  in  some  cases,  the  anesthetic  effect  can  be  restricted  to  a  localized  area  (eg,  the  cornea  or  an  arm).  When  given  intravenously,  local  anesthetics  have  effects  on  other  tissues,  for  example,  heart.