RT Book, Section
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke
A1 Tuan, Rupa Lalchandani
A1 Vanderah, Todd W.
A1 Trevor, Anthony J.
SR Print(0)
ID 1180555497
T1 Drugs Used in Hypertension
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 13e
YR 2021
FD 2021
PB McGraw-Hill Education
PP New York, NY
SN 9781260117127
LK accessmedicine.mhmedical.com/content.aspx?aid=1180555497
RD 2024/04/23
AB Hypertension  is  recognized  as  a  major  risk  factor  for  several  potentially  lethal  cardiovascular  conditions,  including  myocardial  infarction,  heart  failure,  and  stroke.  Guidelines  urge  more  active  prevention  and  treatment  of  hypertension.  According  to  the  guidelines,  average  systolic  pressure  greater  than  120  but  less  than  130  mm  Hg  is  considered  elevated,  pressure  equal  to  or  greater  than  130/80  but  less  than  140/89  mm  Hg  is  considered  stage  1  hypertension,  while  pressures  equal  to  or  greater  than  140/90  mm  Hg  are  considered  stage  2  hypertension.  Increased  systolic  pressure  is  now  considered  at  least  as  important  as  elevated  diastolic.  Both  stage  1  and  stage  2  hypertension  are  deserving  of  treatment  in  most  patients  and  the  guidelines  urge  that  causes  and  treatment  of  atherosclerosis  also  be  considered  (see  Chapter  35).Many  drugs  are  available  for  treatment  of  hypertension  and  in  most  patients  blood  pressure  can  now  be  controlled  effectively  and  with  minimal  adverse  effects.  Antihypertensive  drugs  are  organized  around  a  clinical  indication—the  need  to  treat  the  disease—rather  than  a  single  receptor  type.  The  drugs  covered  in  this  unit  have  a  variety  of  mechanisms  of  action  including  diuresis,  sympathoplegia  (interference  with  the  sympathetic  nervous  system),  vasodilation,  and  antagonism  of  the  renin-angiotensin-aldosterone  system,  and  many  agents  are  available  in  most  of  these  categories.