RT Book, Section A1 V.B. Reddy, Vishnu A1 Morlote, Diana A2 Kaushansky, Kenneth A2 Prchal, Josef T. A2 Burns, Linda J. A2 Lichtman, Marshall A. A2 Levi, Marcel A2 Linch, David C. SR Print(0) ID 1180480978 T1 Anemia Associated with Marrow Infiltration T2 Williams Hematology, 10e YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781260464122 LK accessmedicine.mhmedical.com/content.aspx?aid=1180480978 RD 2024/03/28 AB SUMMARYMyelophthisic anemia is caused by marrow infiltration, typically by metastatic cancer but also by any nonhematopoietic conditions such as granulomatous inflammation or fibrosis. It can present with an overt leukoerythroblastic picture or with only a few teardrop-shaped red cells on a blood film. These changes may represent an early spread of the tumor (or other nonhematopoietic entities) to the marrow or may indicate massive replacement of the marrow space. The diagnosis can be made by standard marrow biopsy. Radioisotope scanning, positron emission tomography/computerized tomography, and magnetic resonance imaging, although not very sensitive, can be helpful in locating the biopsy site and can also help in estimating the percentage of involvement of the marrow space.