RT Book, Section A1 Gregg, Xylina T. A2 Kaushansky, Kenneth A2 Prchal, Josef T. A2 Burns, Linda J. A2 Lichtman, Marshall A. A2 Levi, Marcel A2 Linch, David C. SR Print(0) ID 1180479960 T1 Erythropoietic Effects of Endocrine Disorders T2 Williams Hematology, 10e YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781260464122 LK accessmedicine.mhmedical.com/content.aspx?aid=1180479960 RD 2024/03/28 AB SUMMARYThe endocrine system influences homeostasis of virtually every tissue. Thus, it is not unexpected that it also influences hematopoiesis. However, the effect of the endocrine disequilibrium is principally on erythropoiesis with limited impact on leukocytes, platelets and hemostasis. Thus, anemia is the most common hematopoietic abnormality in endocrine disorders and may be the first manifestation of an endocrine disorder. Erythrocytosis is less common but occurs in certain endocrine disorders. The pathophysiologic basis of the anemia is often multifactorial, but a direct influence of hormones on erythropoiesis in some instances may contribute to anemia. A decreased plasma volume in some of these disorders may mask the severity of anemia. Some endocrine disorders are associated with an impaired response to the therapeutic use of erythropoietin.