RT Book, Section A1 Rezvani, Andrew R. A1 Negrin, Robert S. A2 Kaushansky, Kenneth A2 Prchal, Josef T. A2 Burns, Linda J. A2 Lichtman, Marshall A. A2 Levi, Marcel A2 Linch, David C. SR Print(0) ID 1180478799 T1 Hematopoietic Stem Cell Transplantation T2 Williams Hematology, 10e YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781260464122 LK accessmedicine.mhmedical.com/content.aspx?aid=1180478799 RD 2024/03/28 AB SUMMARYSince its inception in the mid-20th century, the field of hematopoietic cell transplantation (HCT) has evolved from experimental animal models of marrow transplantation to curative therapy for tens of thousands of people yearly who are affected by a wide variety of marrow failure states, myeloid and lymphoid malignancies, immune deficiencies, genetic disorders and inborn errors of metabolism. Advances in transplantation immunobiology and improvements in supportive care have made this evolution possible and have ushered in the modern era of HCT. This chapter discusses the biologic principles and clinical applications of HCT, along with its future applications. Selected results demonstrating important principles are highlighted.