RT Book, Section A1 Lichtman, Marshall A. A2 Kaushansky, Kenneth A2 Prchal, Josef T. A2 Burns, Linda J. A2 Lichtman, Marshall A. A2 Levi, Marcel A2 Linch, David C. SR Print(0) ID 1180444553 T1 Classification and Clinical Manifestations of Neutrophil Disorders T2 Williams Hematology, 10e YR 2021 FD 2021 PB McGraw-Hill Education PP New York, NY SN 9781260464122 LK accessmedicine.mhmedical.com/content.aspx?aid=1180444553 RD 2024/03/29 AB SUMMARYNeutrophil disorders can be grouped into deficiencies (neutropenia), excesses (neutrophilia), or qualitative abnormalities. Neutropenia can have the severe consequence of predisposing to infection, whereas neutrophilia usually is a manifestation of an underlying inflammatory or neoplastic disease, the neutrophilia, per se, having no specific consequences. Qualitative disorders of neutrophils may lead to infection as a result of defective cell translocation to an inflammatory site or defective microbial killing. Neutropenia may reflect an inherited disease that is evident in childhood (eg, congenital [hereditary] severe neutropenia), but more often, it is acquired. A common cause of neutropenia is the adverse effect of a drug. Some cases of neutropenia have no evident cause. The health consequence of neutropenia is a function of the mechanism of the neutropenia, the abruptness and severity of the decrease in the blood neutrophil count, and the duration of the decrease. Neutrophils have also been identified as mediators of vascular or tissue injury. Table 62–1 provides a comprehensive categorization of quantitative and qualitative neutrophil disorders.