RT Book, Section
A1 Cantrell, F. Lee
A2 Olson, Kent R.
A2 Anderson, Ilene B.
A2 Benowitz, Neal L.
A2 Blanc, Paul D.
A2 Clark, Richard F.
A2 Kearney, Thomas E.
A2 Kim-Katz, Susan Y.
A2 Wu, Alan H. B.
SR Print(0)
ID 1179992947
T1 FOLIC ACID
T2 Poisoning & Drug Overdose, 7e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071839792
LK accessmedicine.mhmedical.com/content.aspx?aid=1179992947
RD 2024/04/19
AB Pharmacology.  Folic  acid  is  a  B-complex  vitamin  that  is  essential  for  protein  synthesis  and  erythropoiesis.  In  addition,  the  administration  of  folate  to  patients  with  methanol  poisoning  may  enhance  the  conversion  of  the  toxic  metabolite  formic  acid  to  carbon  dioxide  and  water,  based  on  studies  in  folate-deficient  primates.  Note:  Folic  acid  requires  metabolic  activation  and  may  not  be  effective  for  the  treatment  of  acute  poisoning  by  dihydrofolate  reductase  inhibitors  (eg,  methotrexate  and  trimethoprim).  Leucovorin  is  the  proper  agent  in  these  situations.Indications.  Adjunctive  treatment  for  methanol  poisoning  and  possibly  ethylene  glycol  poisoning.Contraindications.  No  known  contraindications.Adverse  effectsRare  allergic  reactions  have  been  reported  after  intravenous  administration.Use  in  pregnancy.  FDA  Category  A  (Introduction).  Folic  acid  is  a  recommended  supplement.Drug  or  laboratory  interactions.  This  agent  may  decrease  phenytoin  levels  by  enhancing  its  metabolism.Dosage  and  method  of  administration.  The  dose  required  for  methanol  (or  ethylene  glycol)  poisoning  is  not  established,  although  1–2  mg/kg  (typical  doses  are  50–70  mg  IV)  every  4–6  hours  has  been  recommended.  Folic  acid  should  be  readministered  following  hemodialysis  as  it  is  readily  removed  by  the  procedure.FormulationsParenteral.  Sodium  folate  5  mg/mL,  10-mL  vials.Suggested  minimum  stocking  levels  to  treat  a  100-kg  adult  for  the  first  8  hours  and  24  hours:  folate  sodium,  first  8  hours:  100–200  mg  or  2–4  vials  (5  mg/mL,  10  mL  each);  first  24  hours:  300–600  mg  or  6–12  vials  (5  mg/mL,  10  mL  each).