RT Book, Section
A1 Gugelmann, Hallam
A2 Olson, Kent R.
A2 Anderson, Ilene B.
A2 Benowitz, Neal L.
A2 Blanc, Paul D.
A2 Clark, Richard F.
A2 Kearney, Thomas E.
A2 Kim-Katz, Susan Y.
A2 Wu, Alan H. B.
SR Print(0)
ID 1179991962
T1 METHOTREXATE
T2 Poisoning & Drug Overdose, 7e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071839792
LK accessmedicine.mhmedical.com/content.aspx?aid=1179991962
RD 2024/04/25
AB Methotrexate,  or  N-(4-{[(2,4-diamino-6-pteridinyl)methyl]-methylamino}benzoyl)-L-glutamic  acid,  is  an  antimetabolite  chemotherapeutic  agent  that  is  also  used  for  psoriasis,  rheumatoid  arthritis,  systemic  sclerosis,  placenta  accreta,  and  ectopic  pregnancy.  Most  toxicity  is  caused  by  chronic  oral  overmedication.  Inadvertent  high-dose  intrathecal,  intravenous,  and  intramuscular  methotrexate  administration  and  acute  intentional  overdose  have  been  reported.