RT Book, Section
A1 Blanc, Paul D.
A2 Olson, Kent R.
A2 Anderson, Ilene B.
A2 Benowitz, Neal L.
A2 Blanc, Paul D.
A2 Clark, Richard F.
A2 Kearney, Thomas E.
A2 Kim-Katz, Susan Y.
A2 Wu, Alan H. B.
SR Print(0)
ID 1179991947
T1 METHEMOGLOBINEMIA
T2 Poisoning & Drug Overdose, 7e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071839792
LK accessmedicine.mhmedical.com/content.aspx?aid=1179991947
RD 2024/04/25
AB Methemoglobin  is  an  oxidized  form  of  hemoglobin.  Many  oxidant  chemicals  and  drugs  are  capable  of  inducing  methemoglobinemia.  Selected  agents  include  nitrites  and  nitrates,  bromates  and  chlorates,  aniline  derivatives,  some  pesticides  (indoxacarb,  metaflumizone,  propanil),  antimalarial  agents,  rasburicase,  sulfonamides,  dapsone,  and  local  anesthetics  (exposure  to  these  can  occur  topically)  (Table  II–39).  High-risk  occupations  include  chemical  and  munitions  work.  An  important  environmental  source  for  methemoglobinemia  in  infants  is  nitrate-contaminated  well  water.  Amyl  nitrite  and  butyl  nitrite  are  abused  for  their  alleged  sexual  enhancement  properties.  Oxides  of  nitrogen  and  other  oxidant  combustion  products  make  smoke  inhalation  an  important  potential  cause  of  methemoglobinemia.