RT Book, Section
A1 Born, Stephen C.
A2 Olson, Kent R.
A2 Anderson, Ilene B.
A2 Benowitz, Neal L.
A2 Blanc, Paul D.
A2 Clark, Richard F.
A2 Kearney, Thomas E.
A2 Kim-Katz, Susan Y.
A2 Wu, Alan H. B.
SR Print(0)
ID 1179991298
T1 DIOXINS
T2 Poisoning & Drug Overdose, 7e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071839792
LK accessmedicine.mhmedical.com/content.aspx?aid=1179991298
RD 2024/04/19
AB Polychlorinated  dibenzodioxins  (PCDDs)  and  dibenzofurans  (PCDFs)  are  a  group  of  highly  toxic  substances  commonly  known  as  dioxins.  Dioxins  are  not  produced  commercially.  They  are  formed  during  the  production  of  certain  organochlorines  (eg,  trichlorophenoxyacetic  acid  [2,4,5-T],  hexachlorophene,  pentachlorophenol);  and  by  the  combustion  of  these  and  other  compounds,  such  as  polychlorinated  biphenyls  (PCBs),  as  well  as  the  incineration  of  medical  and  municipal  waste.  Agent  Orange,  an  herbicide  used  by  the  United  States  during  the  Vietnam  War,  contained  dioxins  (most  importantly,  2,3,7,8-tetrachlorodibenzo-p-dioxin  [TCDD],  the  most  toxic  and  extensively  researched  dioxin)  as  contaminants.  There  are  75  PCDD  and  135  PCDF  congeners.  Some  PCBs  have  biological  activity  similar  to  that  of  dioxins  and  are  identified  as  "dioxin-like."  The  most  common  route  of  exposure  to  dioxins  in  the  United  States  is  through  dietary  consumption.