RT Book, Section
A1 Anderson, Ilene B.
A2 Olson, Kent R.
A2 Anderson, Ilene B.
A2 Benowitz, Neal L.
A2 Blanc, Paul D.
A2 Clark, Richard F.
A2 Kearney, Thomas E.
A2 Kim-Katz, Susan Y.
A2 Wu, Alan H. B.
SR Print(0)
ID 1179991253
T1 DEXTROMETHORPHAN
T2 Poisoning & Drug Overdose, 7e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071839792
LK accessmedicine.mhmedical.com/content.aspx?aid=1179991253
RD 2024/04/23
AB Dextromethorphan  is  a  common  antitussive  agent  found  in  many  over-the-counter  (OTC)  cough  and  cold  preparations.  Dextromethorphan  is  often  found  in  combination  products  containing  antihistamines,  decongestants,  ethanol,  or  acetaminophen.  Common  combination  products  containing  dextromethorphan  include  Coricidin  HBP  Cough  &  Cold  Tablets,  Robitussin  DM,  and  NyQuil  Nighttime  Cold  Medicine.  Dextromethorphan  is  well  tolerated  at  therapeutic  doses,  and  serious  toxicity  rarely  occurs,  even  with  moderate-to-high  doses.  However,  major  toxicity  and  death  have  been  reported,  caused  either  by  dextromethorphan  as  a  sole  agent  or  more  commonly  by  coingestants,  drug–drug  interactions,  or  genetic  polymorphism.  Intentional  abuse,  especially  among  adolescents  and  young  adults,  has  been  a  continuing  problem  owing  to  the  hallucinogenic  potential  at  high  doses.  Common  slang  terms  include  "triple  C,"  "CCC,"  "skittles,"  "robo,"  "DXM,"  and  "dex."  "Crystal  Dex"  and  "DXemon  Juice"  refer  to  dextromethorphan  extracted  from  the  other  ingredients  in  OTC  cold  medications  using  simple  home  acid–base  extraction  techniques.