RT Book, Section
A1 Lewis, Justin C.
A2 Olson, Kent R.
A2 Anderson, Ilene B.
A2 Benowitz, Neal L.
A2 Blanc, Paul D.
A2 Clark, Richard F.
A2 Kearney, Thomas E.
A2 Kim-Katz, Susan Y.
A2 Wu, Alan H. B.
SR Print(0)
ID 1179990620
T1 ANTIPSYCHOTIC DRUGS, INCLUDING PHENOTHIAZINES
T2 Poisoning & Drug Overdose, 7e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9780071839792
LK accessmedicine.mhmedical.com/content.aspx?aid=1179990620
RD 2024/04/16
AB Phenothiazines,  butyrophenones,  and  other  related  drugs  are  used  widely  to  treat  psychosis  and  agitated  depression.  In  addition,  some  of  these  drugs  (eg,  prochlorperazine,  promethazine,  trimethobenzamide,  and  droperidol)  are  used  as  antiemetic  agents.  Suicidal  overdoses  are  common,  but  because  of  the  high  toxic-therapeutic  ratio,  acute  overdose  seldom  results  in  death.  A  large  number  of  newer  agents  that  often  are  referred  to  as  "atypical  antipsychotics"  have  been  developed.  Atypical  antipsychotics  differ  from  other  neuroleptics  in  their  binding  to  dopamine  receptors  and  their  effects  on  dopamine-mediated  behaviors.  Overdose  experience  with  these  agents  is  limited.  Table  II–11  describes  available  antipsychotic  agents.