RT Book, Section A1 Burns, Lawton Robert SR Print(0) ID 1184094246 T1 The Pharmaceutical Sector T2 The U.S. Healthcare Ecosystem: Payers, Providers, Producers YR 2021 FD 2021 PB McGraw-Hill PP New York, NY SN 9781264264476 LK accessmedicine.mhmedical.com/content.aspx?aid=1184094246 RD 2024/04/23 AB This chapter and the next examine the sectors that manufacture pharmaceuticals and biologics. By way of definition, a pharmaceutical is a product made through chemical synthesis (ie, the preparation of a compound using plant- and chemical-based substances that use chemical reactions to derive a pill or capsule). By contrast, a biologic is manufactured in or extracted from living biological sources (eg, bacteria, yeast, and mammalian cells) and can include vaccines, allergenics, somatic cells, gene therapies, tissues, recombinant therapeutic proteins (including monoclonal antibodies), peptides (protein fragments), and living cells. An easier way to distinguish these 2 products is that pharmaceuticals are small molecules (700 daltons) that are usually administered by a physician via an injection, but can sometimes be patient-administered via an auto-injector.