RT Book, Section A1 Katzung, Bertram G. A1 Kruidering-Hall, Marieke A1 Trevor, Anthony J. SR Print(0) ID 1179227181 T1 Immunopharmacology T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 12e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259641022 LK accessmedicine.mhmedical.com/content.aspx?aid=1179227181 RD 2024/03/28 AB The immune system is essential for protection against pathogens. However, when dysregulated, its powerful destructive mechanisms do more harm than good. Examples include hypersensitivity reactions, autoimmune disorders, and rejection of transplanted tissues. Drugs that suppress immune mechanisms play an important role in treating these conditions. Increasingly, monoclonal antibodies targeting proteins with key roles in immune responses are being developed as immunosuppressive agents. In some situations, drugs that potentiate the immune response provide benefit. A growing number of other conditions now rely on monoclonal antibodies as therapeutics (cancer, cardiovascular conditions, HIV, etc). A small subset of these newer drugs has been withdrawn from the market based on emerging toxicities.